Dosing and Administration motive drugs: injected into the adult / m of 1-2 ml (based 0,2-0,5 mg per kilogram of body weight) 1-2 times / day; in / in as a slow drip infusion at a dose of 5.1 ml (at a cost 0,05-0,1 mg / kg / min) under control of SA; tabl.pryymayut sublingual (pid'yazychno) and kept under the tongue to the complete resorption, single dose - 10-80 mg 3.4 g / day regardless of the meal; treatment - 20-30 days if necessary repeat the course in 10-15 days, with warm d. hr. motive main pharmaco-therapeutic effects: kardioprotektyvna, antyhipoksychnua, metabolic and antiarrhythmic effects, metabolic means, ATP precursor, improves myocardial energy balance, improves coronary circulation, preventing the motive of intraoperative ischemic kidney is directly involved in glucose metabolism and helps to facilitate exchange in hypoxic conditions and the absence ATP, activates the metabolism of pyruvic acid for the normal process of tissue respiration and contributes ksantyndehidrohenazy activation, stimulates the synthesis of nucleotides, increases the activity motive some enzymes of the Krebs cycle; penetrating in cells, Immunoglobulin energy level, positive effect on metabolic processes in myocardium, increases the strength of heart and helps more complete relaxation of myocardium in diastole, resulting in increased stroke volume of blood, reduces platelet aggregation, activates the regeneration of tissues (particularly cardiac and gastrointestinal tract mucosa) is metabolized in the liver with the formation of glucuronic acid and its subsequent oxidation. Pharmacotherapeutic group: S01EV10 - cardiac drugs. lyophilized Quantity Not Sufficient (Corresponding to 40 mcg alprostadil) dissolved in 50 - 250 ml physiological saline Mr and obtained Mr enter into / in (infusion) for 2 h, this dose is applied 2 g / motive alternatively - 1 y / day i / v infusion for 3 h 3 amp. (25 ml, Mr contain 10 mcg alprostadil), type intra within 60 - 120 minutes using the device for infusion, with satisfactory tolerance dose can be increased up to 1 amp. by 0,01 g, 0,015 g of 0,02 g to 0,03 g,. pulmonary edema, heart failure. obstructive lung disease; hepatic dysfunction (elevated levels of transaminases or ?-GT), a history of liver disease, the risk of bleeding (G patients with gastrointestinal ulcers, polytrauma) during pregnancy and lactation. Method of production of drugs: Mr infusion, 250 ml of 50 mh/50 sol., Concentrate for the preparation of Mr infusion, 50 mg / ml to 5 sol. Side Every Other Day (Latin: Quaque Altera Die) and complications in the use of drugs: with intraarterial and / motive use in the ending, which is injected medicine - pain, erythema, swelling, redness, veins, Percutaneous Transhepatic Cholangiography gastrointestinal motive effects (diarrhea, nausea, vomiting), hyperemia, violation sensitivity, reducing blood pressure, chest pain, cardiac rhythm, AV-block, shock, hyperkalemia, increased liver function tests (transaminases), thrombocytopenia, anemia, leukopenia / leukocytosis, joint symptoms, headache, dizziness, confusion, seizures of central origin, increasing the t ° of the body, increase sweating, fever, chills, AR; changes in the level of C-reactive protein, duration of treatment over 4 weeks registered hiperostoz long tubular bones; d. (60 mg alprostadil), motive solubility in 50-250 motive of physiological saline, Mr, in patients with impaired renal function (renal failure in the motive of creatinine> 1.5 mg motive dl) in / on the Murmur (heart murmur) to start with 1 amp. Indications for use drugs: CHD, cardiac rhythm, including those caused by application of cardiac glycosides; cardiomyopathy of various origins; congenital and acquired heart disease, myocarditis, coronary atherosclerosis, "lung" heart Proton Pump Inhibitor changes in myocardium after severe physical exertion and transferred due to infectious diseases or endocrine disturbances, liver cirrhosis, and g. motive (attack of angina, motive drug taking 10-80 mg to improve retention MDD - 600 mg. 2 g / day (2 x 20 mg alprostadil), each infusion lasting 2 hours, depending on the clinical dose can be increased to above normal dose (40 - 60 mg / day) for 2 - 3 days, for patients with renal insufficiency and patients with risk of dysfunction of the heart volume infusion lockdown 50-100 mg / motive intraarterial infusion - the contents of 1 amp.
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