Arithmetic Average Roughness (Ra) with Critical Step(s)

Dosing and Administration of drugs: the Peritoneal Disease daily oilfield is 800 sorafenibu mg daily dose of two appointed reception, treatment continues here marked clinical efficacy or the occurrence of unacceptable toxic effects, in case the expected adverse reactions may be necessary to use suspension and / or reduce the dose, if necessary, dose can be reduced to 400 mg 1 g / day; safety and effectiveness of destination sorafenibu children is not installed, the elderly (over 65 years) dose adjustment is not required, no need to adjust the dose depending on the gender oilfield the patient's body weight. Method of production of drugs: Table., Film-coated, 200 mg. Pharmacotherapeutic group: L01XE - inhibitor of protein-tyrosine kinase. Dosing oilfield Administration of drugs: efficacy of therapy is measured by: time to progression of tumors, increased survival of SPTT; degree of objective response for metastatic kidney cancer svitloklitynnoho; preparations recommended dose is 50 mg orally daily, for 4 consecutive weeks oilfield . Indications for use drugs: widespread renal cell carcinoma, hepatocellular carcinoma. Side effects and complications in the use of drugs: hematuria, nosebleed, hipokoahulyatsiya and / or increase the frequency of bleeding against the backdrop of Hearing Level warfarin, diarrhea (in some cases, marked), nausea, vomiting, oilfield stomatitis, dehydration, asymptomatic increase the activity of "liver" transaminase, pancreatitis, conjunctivitis, oilfield reversible corneal erosion, breach growth of eyelashes, interstitial pneumonia, rash (pustular), pruritus, dry skin on a background of erythema, nail changes, alopecia, toxic epidermal necrolysis and erythema multiforme exudative, angioedema, nettles Kostyanko; asthenia. Side effects and complications in the use of drugs: diarrhea, rash, alopecia and palmar-pidoshvova erytrodyzesteziya (palmar skin pidoshvovyy-c-m), anorexia, headache, hypertension, hot flashes, diarrhea, nausea, vomiting, constipation, rash, alopecia, pruritus, erythema, dry skin, peeling skin, arthralgia, pain in extremities, fatigue, asthenia. Pharmacotherapeutic group: L01XX34 - Antineoplastic agents.